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pentobarbital will minimize the extent or result of ambrisentan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unfamiliar.pentobarbital will reduce the extent or outcome of tramadol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Diminished AUC of tramadol and the Lively metabolite (O-des